![]() Drug is released slowly from the dosage form by a process of diffusion through the gel matrix that is essentially independent of pH. After administration, fluid from the gastrointestinal (GI) tract enters the tablet, causing the polymers to hydrate and swell. Metformin hydrochloride, USP is combined with a drug release controlling polymer to form an "inner" phase, which is then incorporated as discrete particles into an "external" phase of a second polymer. System Components and Performance - Metformin hydrochloride extended-release tablets, USP comprises a dual hydrophilic polymer matrix system. Metformin hydrochloride extended-release tablets, USP 500 mg tablets contain the inactive ingredients hypromellose, magnesium stearate, and polyvinyl pyrrolidone. Metformin hydrochloride extended-release tablets, USP contain 500 mg of metformin hydrochloride as the active ingredient. The pH of a 1% aqueous solution of metformin hydrochloride is 6.35. ![]() Metformin hydrochloride is freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in Methylene chloride. Metformin hydrochloride, USP is a white or almost white, crystalline powder with a molecular formula of C4H11N5 Metformin hydrochloride, USP (N,N-dimethyl-monohydrochloride,Imidodicarbonimidic diamide) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin hydrochloride extended-release tablets, USP are oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin Hydrochloride Extended-Release Tablets, USP
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